N-(6-chloro-2-phenyl-4-pyrimidinyl)-N,N-dimethylamine synthesis

Yield:-

Reaction Conditions:

Stage #1: fenclorim;dimethyl amine in tetrahydrofuran;water at 20; for 3 h;
Stage #2: with sodium hydrogencarbonate in tetrahydrofuran;chloroform;water;

Steps:

178.A

To a solution of 4, 6-dichloro-2-phenylpyrimidine (2.00 g) in THF (10 mL) was added 50% aqueous Me2NH (2. 30 mL) and the mixture was stirred at ambient temperature for 3 h. The mixture was diluted with CHC13 and added to saturated aqueous NaHC03. The aqueous layer was extracted with CHCl3 (three times). The combined organic layer was dried over MgS04, filtrated, concentrated under reduced pressure, and dried under reduced pressure to give the title compound (2.05 g). 'H NMR (300 MHz, CDCl3, 8) : 3.19 (brs, 6H), 6.34 (s, 1H), 7.39-7. 49 (m, 3H), 8. 35-8. 45 (m, 2H) ; ESI MS m/z 234 (M++1, 100%).

References:

WO2005/95357,2005,A2 Location in patent:Page/Page column 171