Apraclonidine hydrochloride synthesis
- Product Name:Apraclonidine hydrochloride
- CAS Number:73218-79-8
- Molecular formula:C9H11Cl3N4
- Molecular Weight:281.57
66711-21-5
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73218-79-8
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Yield:73218-79-8 72.1%
Reaction Conditions:
with hydrogenchloride in methanol; for 2 h;Reflux;Solvent;
Steps:
3 Example 3
2- (2 ', 6'-Dichloro-4'-nitroanilino)-2-imidazoline27.4 g (0.1 mol),Hydrazine hydrate 11.8g (0.2mol),Added methanol 200mL, 5% palladium carbon 0.3g,Plus heating reaction mixture was stirred for 2h,Cool, hot filtered.The filtrate was added hydrochloric acid 10mL, heated to reflux for 2 hours,Chilled to give a white solid Apraclonidine hydrochloride 20.2, yield 72.1%
References:
CN104557716,2017,B Location in patent:Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048-0057
99-30-9
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73218-79-8
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70106-94-4
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73218-65-2
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73218-79-8
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