BenzenesulfonaMide, 4-(1-piperazinyl)- synthesis
- Product Name:BenzenesulfonaMide, 4-(1-piperazinyl)-
- CAS Number:170856-87-8
- Molecular formula:C10H15N3O2S
- Molecular Weight:241.31
110-85-0
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402-46-0
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$11.00/1g
170856-87-8
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$246.97/5g
Yield:170856-87-8 94%
Reaction Conditions:
in lithium hydroxide monohydrate at 100; for 24 h;
Steps:
5 Step 5: 4-piperazin-1-ylbenzenesulfonamide
A mixture of 4-fluorobenzenesulfonamide (25.0 g, 142.71 mmol) and piperazine (49.17 g, 570.84 mmol) in water (300 mL) was heated at 100° C. for 24 h. The resulting precipitate was collected by filtration, washed with water and toluene, and dried under reduced pressure to give 4-piperazin-1-ylbenzenesulfonamide (32.3 g, 94% yield). 1H NMR (300 MHz, DMSO-d6) δ 7.61 (d, J=9.0 Hz, 2H), 7.06 (s, 2H), 7.01 (d, J=9.0 Hz, 2H), 3.21-3.15 (m, 4H), 2.86-2.77 (m, 4H).
References:
US2021/346405,2021,A1 Location in patent:Paragraph 0457-0458
