ChemicalBook CAS DataBase List Benzoyl chloride

Benzoyl chloride synthesis

15synthesis methods

Product Name:Benzoyl chloride
CAS Number:98-88-4
Molecular formula:C7H5ClO
Molecular Weight:140.57

Benzoyl chloride can be prepared from benzoic acid by reaction with PCl5 or SOCl2, from benzaldehyde by treatment with POCl3 or SO2 Cl2, from benzotrichloride by partial hydrolysis in the presence of H2SO4 or FeCl3, from benzal chloride by treatment with oxygen in a radical source, and from several other miscellaneous reactions. Benzoyl chloride can be reduced to benzaldehyde, oxidized to benzoyl peroxide, chlorinated to chlorobenzoyl chloride and sulfonated to m-sulfobenzoic acid. It will undergo various reactions with organic reagents. For example, it will add across an unsaturated (alkene or alkyne) bond in the presence of a catalyst to give the phenylchloroketone:

65-85-0 Synthesis

65-85-0
1330 suppliers
$10.00/25g

98-88-4
571 suppliers
$10.00/5g

Yield:98-88-4 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 35; for 1 h;

Steps:

Syntheses of Aryl Acid Chlorides (4a-f)

General procedure: The reaction scheme for the syntheses of aryl acid chlorides (4a-f) is shown in Scheme (1). Into a 250 mL two neck round bottomed flask equipped with a mechanical stirrer and a dropping funnel was placed in a thermostat bath. To a stirred solution of aryl acid (3a-f) 8 mM (3a: 0.98 g; 3b: 1.22g; 3c: 1.09 g; 3d: 1.34 g; 3e: 1.34 g; 3f: 1.18 g) in 100 mL CH₂Cl₂ at room temperature was added 16 mM (2.02 g) oxalyl chloride, 2 drops of DMF and the mixture was stirred at room temperature for 1h. The resulting mixture was concentrated under reduced pressure to afford acid chloride quantitatively and stored in air tight flask.

References:

Patel, Chirag Bhupendra;Dhaduk, Bhavin Babu;Parsania, Parsotam Hari [Letters in drug design and discovery,2015,vol. 12,# 6,p. 505 - 511]

98-86-2 Synthesis

98-86-2
738 suppliers
$9.00/5g

98-88-4
571 suppliers
$10.00/5g

References

774-65-2 Synthesis

774-65-2
63 suppliers
$45.00/25mL

98-88-4
571 suppliers
$10.00/5g

References

100-52-7 Synthesis

100-52-7
947 suppliers
$20.37/250g

98-88-4
571 suppliers
$10.00/5g

References

98-07-7 Synthesis

98-07-7
322 suppliers
$13.00/25g

98-88-4
571 suppliers
$10.00/5g

References

Benzoyl chloride Related Search:

2-Chlorobenzoyl chloride Benzyl chloride Calcium chloride Choline chloride Terephthaloyl chloride Bethanechol Sodium chloride N-Acetylsulfanilyl chloride Ammonium chloride Benzoyl peroxide