ChemicalBook CAS DataBase List Citalopram hydrobromide

Citalopram hydrobromide synthesis

11synthesis methods

Product Name:Citalopram hydrobromide
CAS Number:59729-32-7
Molecular formula:C20H22BrFN2O
Molecular Weight:405.3

59729-33-8
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59729-32-7
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Yield:59729-32-7 88.2%

Reaction Conditions:

with hydrogen bromide in water;isopropyl alcohol; pH=6 - 7

Steps:

4
10g citalopram obtained in Example3 was heated and dissolved in 40mL isopropanol. After cooled down, pH of the solution was adjusted to 6-7 with bromic acid. The mixture was disposed with active carbon and filtrated, cooled down and placed aside to crystallize. Then the solution was filtrated and washed to give citalopram hydrobromic salt crystal. The obtained salt crystal was recrystallized to give 9.82g citalopram hydrobromic salt crystal with the yield of 88.2% and the purity of 99.9% (HPLC, area normalization method).

References:

Hangzhou Minsheng Pharm. Co., Ltd. EP1700851, 2006, A1 Location in patent:Page/Page column 10

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