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ChemicalBook CAS DataBase List Cocal

Cocal synthesis

2synthesis methods
From phenyl acetaldehyde and isopropyl acetaldehyde by aldolic condensation
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: tBuOK; 18-crown-6 / tetrahydrofuran / 20 °C
1.2: tetrahydrofuran / -78 °C
2.1: Amberlyst 15; H2O / acetone / 20 °C

References:

Tago, Keiko;Arai, Masami;Kogen, Hiroshi [Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,# 13,p. 2073 - 2078]

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