Difluoroacetic acid synthesis
- Product Name:Difluoroacetic acid
- CAS Number:381-73-7
- Molecular formula:C2H2F2O2
- Molecular Weight:96.03
454-31-9
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381-73-7
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383-63-1
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Yield:381-73-7 99%
Reaction Conditions:
at 85;Product distribution / selectivity;
Steps:
3
Ethyl difluoroacetate (60 g, 0.484 mol) is brought together with trifluoroacetic acid (56 g, 0.484 mol, 1 equivalent) in a glass reactor surmounted by a distillation column.The reaction medium is brought to the temperature of 85° C. at atmospheric pressure.Ethyl trifluoroacetate is distilled off while keeping the temperature of the distillation top at 63° C.A fraction of 69 g of ethyl trifluoroacetate is obtained.All of the ethyl difluoroacetate was consumed (DC=100%) and the difluoroacetic acid obtained at the distillation bottom has a purity of 99.5% by weight.The yield (RY) is greater than 99%.
References:
US2012/123159,2012,A1 Location in patent:Page/Page column 4
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381-73-7
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381-73-7
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381-73-7
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