Dimorpholino thioketone synthesis
- Product Name:Dimorpholino thioketone
- CAS Number:1013-93-0
- Molecular formula:C9H16N2O2S
- Molecular Weight:216.3
Yield:1013-93-0 75 %
Reaction Conditions:
with sulphur in dimethyl sulfoxide at 100;
Steps:
4
Add sublimated sulfur M1 (192mg, 6.0mmol), malonic acid M2 (156mg, 1.5mmol), and morpholine M5 (174mg, 2mmol) into a 10mL polymerization tube. Methyl sulfoxide, and stirred and reacted at 100 degrees Celsius at a speed of 500 r/min for 8 hours. After the reaction, wait for it to cool to room temperature, add 50mL ethyl acetate and 50mL water, extract three times, then collect the organic layer liquid and dry it, and wash it with a mixture of petroleum ether and ethyl acetate at a volume ratio of 5:1 by silica gel chromatography After separation, purification and drying, the yellow solid thiourea Compound 3 was obtained with a yield of 75%.
References:
CN115417799,2022,A Location in patent:Paragraph 0081-0088
