Fmoc-D-4-Hydroxyphenylglycine synthesis
- Product Name:Fmoc-D-4-Hydroxyphenylglycine
- CAS Number:178119-93-2
- Molecular formula:C23H19NO5
- Molecular Weight:389.4
22818-40-2
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28920-43-6
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$5.00/5g
178119-93-2
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$108.00/1g
Yield:178119-93-2 95%
Reaction Conditions:
with sodium hydrogencarbonate in tetrahydrofuran;water; for 8.41667 h;
Steps:
1 Example 1
Compound I-1 (31.0 mmol) was dissolved in 200 mL of a 1: 1 mixture of tetrahydrofuran and water, and Fmoc-Cl (32.5 mmol) and sodium bicarbonate (33.0 mmol) in 50 mL of tetrahydrofuran were added dropwise over 25 minutes. ). The mixed solution was stirred for 8 hours, then diluted with water and extracted with ether. The aqueous phase was acidified to pH = 3 and extracted with ethyl acetate. The combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and the organic solvent was removed by rotary evaporation under reduced pressure. The obtained crude product was recrystallized from ethyl acetate: petroleum ether (5: 1) to obtain a white solid, which is Compound I-2 (yield: 95%,
References:
CN110551144,2019,A Location in patent:Paragraph 0027-0029
22818-40-2
443 suppliers
$7.00/10g
82911-69-1
599 suppliers
$7.00/25g
178119-93-2
40 suppliers
$108.00/1g