H2N-PEG4-tBu synthesis
- Product Name:H2N-PEG4-tBu
- CAS Number:581065-95-4
- Molecular formula:C15H31NO6
- Molecular Weight:321.41
581065-94-3
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$135.00/1G
581065-95-4
137 suppliers
$42.00/100mg
Yield:581065-95-4 50 g
Reaction Conditions:
with ammonium hydroxide;tetrabutylammomium bromide in dichloromethane at 40; for 24 h;
Steps:
1.3
The 150 g of the sulfonylated crude product obtained in step (2) was added to 200 ml of methylene chloride,Then add 100g ammonium hydroxide,10g tetrabutylammonium bromide,Warmed to 40 ,Stir for 24h.The reaction is over,Spin dry,Add 3M hydrochloric acid,Adjust PH = 3,With 300ml of dichloromethane,Extract 2 times,Then use sodium hydroxide solution to adjust PH = 9,Then extracted three times with 400ml of dichloromethane,Dried over anhydrous sodium sulfate,Spin dry,50 g of amino-terminated product was obtained.NMR data are as follows:
References:
Hunan Huateng Pharmaceutical Co., Ltd.;Deng Zeping;Li Hu;Cheng Jia CN107235848, 2017, A Location in patent:Paragraph 0021
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112-60-7
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581065-95-4
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$42.00/100mg
1663-39-4
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581065-95-4
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$42.00/100mg
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581065-95-4
137 suppliers
$42.00/100mg