Lauryl chloroformate synthesis
- Product Name:Lauryl chloroformate
- CAS Number:24460-74-0
- Molecular formula:C13H25ClO2
- Molecular Weight:248.79
112-53-8
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32315-10-9
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24460-74-0
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$6.00/25g
Yield: 100%
Reaction Conditions:
with pyridine in tetrachloromethane at -15 - 20;
Steps:
4.A Step A: dodecyl carbonochloridate.
To a stirred solution of dodecan-1 -ol (373 mg, 2.0 mmol) and pyridine (0.178 ml_, 2.200 mmol) in CCI4(20 ml_) cooled in an ice-salt mixture was added triphosgene (593 mg, 2.000 mmol). The mixture was stirred for several minutes at -15 °C and then warmed to ambient temperature and stirred overnight. The mixture was diluted with ether, then filtered over Celite. The filtrate was concentrated to afford dodecyl carbonochloridate (531 mg, quantitative yield) as a colorless oil.1H NMR (400 MHz, CDCb) d = 4.32 (t, J = 6.6 Hz, 2H), 1 .81 - 1 .65 (m, 2H), 1 .45 - 1 .22 (m, 18H), 0.94 - 0.82 (m, 3H).
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED;VIIV HEALTHCARE COMPANY;MILLER, John;TEMELKOFF, David;VELTHUISEN, Emile Johann;DE LA ROSA, Martha Alicia;SUWANDI, Lita S. WO2020/44257, 2020, A1 Location in patent:Page/Page column 42; 43
