ChemicalBook CAS DataBase List N-(2-Hydroxyethyl)pyrrolidine

N-(2-Hydroxyethyl)pyrrolidine synthesis

12synthesis methods

Product Name:N-(2-Hydroxyethyl)pyrrolidine
CAS Number:2955-88-6
Molecular formula:C6H13NO
Molecular Weight:115.17

123-75-1 Synthesis

123-75-1
536 suppliers
$10.00/5g

540-51-2
228 suppliers
$17.00/5g

2955-88-6
248 suppliers
$8.00/5g

Yield:2955-88-6 83%

Reaction Conditions:

in tetrahydrofuran; for 36 h;Heating / reflux;

Steps:

58

Intermediate (58) : Preparation of 2-(methyl-propyl-amino)-ethanol; Pyrrolidine (0.835ml, lOmmol) and 2-bromoethanol (0.28ml, 4.0mmol) were dissolved in THF (10ml). The reaction mixture was refluxed for 36 hours. The solvent was removed under reduced pressure. The residue was purified by column chromatography (dichlorome thane: methanol = 10:1) to give 380mg (yield: 83%, brown oil) of the target compound.[1141] ¹U NMR(400D, CDCI): δ 3.64(t, J=5.6Hz, 2H), 2.65(t, J=5.6Hz, 2H), 2.56(m, 4H),1.78(m, 4H)

References:

WO2007/102679,2007,A1 Location in patent:Page/Page column 106

123-75-1 Synthesis

123-75-1
536 suppliers
$10.00/5g