ChemicalBook CAS DataBase List N-CAPROIC ACID ISOPROPYL ESTER

N-CAPROIC ACID ISOPROPYL ESTER synthesis

10synthesis methods

Product Name:N-CAPROIC ACID ISOPROPYL ESTER
CAS Number:2311-46-8
Molecular formula:C9H18O2
Molecular Weight:158.24

By esterification of hexanoic acid with isopropyl alcohol in benzene solution in the presence of trace amounts of concentrated H2SO4 and subsequent azeotropic distillation

504-60-9 Synthesis

504-60-9
88 suppliers
$180.00/1ml

201230-82-2 Synthesis

201230-82-2
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67-63-0 Synthesis

67-63-0
1548 suppliers
$16.00/25ML

2311-46-8
85 suppliers
$14.00/1mL

Yield:-

Reaction Conditions:

Stage #1:penta-1,3-diene;isopropyl alcohol with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;methanesulfonic acid;1,2-bis[di(t-butyl)phosphinomethyl]benzene in methanol for 0.25 h;Sonication;Schlenk technique;
Stage #2:carbon monoxide with hydrogen in methanol under 22502.3 Torr;

Steps:

4 Standard experimental procedure
General procedure: All screening experiments were performed in a 20 ml home-made multiplex reactor [48]. In an typical experiment 87.5 mg(0.10 mmol) Pd2(dba)3 and 301.8 mg (0.75 mmol) 1,2-dtbpmb,869.1 mg (12.75 mmol) piperylene, 98.0 mg (1.02 mmol) methane-sulfonic acid and 10 ml methanol were placed in a Schlenck-vessel.The mixture was placed in an ultrasonic bath for 15 min. The mix-ture was transferred to an evacuated and ame-dried reactor andsubsequently charged with 30 bar synthesis gas. The mixture wasplaced in an oil bath at reaction temperature e.g. 110 C for vehours. After cooling to room temperature the mixture was depres-surised and analysed by GC-FID.

References:

Neubert, Peter;Steffen, Matthias;Behr, Arno [Journal of Molecular Catalysis A: Chemical,2015,vol. 407,p. 122 - 127]

2396-80-7 Synthesis