N,N-DIBENZYL GLYCINE METHYL ESTER synthesis
- Product Name:N,N-DIBENZYL GLYCINE METHYL ESTER
- CAS Number:94226-55-8
- Molecular formula:C17H19NO2
- Molecular Weight:269.34
Yield:94226-55-8 95.9%
Reaction Conditions:
with potassium carbonate in acetonitrile at 20;
Steps:
1 Step 1:
To a stirred suspension of methyl 2-aminoacetate hydrochloride (20.0 g, 159 mmol) in dry acetonitrile (350 ml) was added potassium carbonate (55.0 g, 398 mmol). To the stirred mixture was added dropwise (bromomethyl)benzene (54.5 g, 319 mmol, 38 ml). The reaction mixture was stirred at r.t. overnight, filtered and the filtrate was concentrated to afford methyl 2- (dibenzylamino)acetate (41.2 g, 153 mmol, 95.9% yield) as colorless oil.
References:
WO2019/86141,2019,A1 Location in patent:Page/Page column 80
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