ChemicalBook CAS DataBase List PHENYL TRIFLUOROACETATE

PHENYL TRIFLUOROACETATE synthesis

13synthesis methods

Product Name:PHENYL TRIFLUOROACETATE
CAS Number:500-73-2
Molecular formula:C8H5F3O2
Molecular Weight:190.12

14353-88-9 Synthesis

[BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE

14353-88-9
74 suppliers
$19.00/100mg

76-05-1 Synthesis

76-05-1
675 suppliers
$9.00/1g

71-43-2
671 suppliers
$11.19/25ML

500-73-2
98 suppliers
$10.00/1g

Yield:-

Reaction Conditions:

with trifluoroacetic anhydride at 100; for 3 h;Temperature;

Steps:

Heating a 100 mM solution of C₆F₅-Iⁱⁿ(TFA)₂ at 150°C for 3 hrs in 100 mM TFAA/HTFA under 500 psi of methane or ethane (125 psi for PrH) was shown by the ¹H-NMR of the crude reaction mixtures to generate the respective trifluoroacetate (TFA) mono-esters and 1 ,2-TFA-diesters (for EtH and PrH) as shown in Eq. 9: R-H + C₆F₅-l'"(TFA)₂ R-TFA + C₆F₅-l' + HTFA TFAA HTFA (R = Me, Et, Pr, Ph) gq 9 1361.193W01 / TSRI Case 1560.1 PCT / FLA0129P Table 4. Conversions of Unactivated Hydrocarbons with Iodine, Selenium, and Tellurium Reagents The reactions are highly selective and no hydrocarbon derived products are observed besides the respective mono- and 1,2-di-esters (Table 5). ¹⁹F-NMR analysis of the solutions post-reaction showed that C₆F₅-Iⁿⁱ(TFA)₂ is converted to C₆F₅-I¹, as the reaction proceeds with no intermediate iodine species observed.

References:

THE SCRIPS RESEARCH INSTITUTE;PERIANA, Roy;HASHIGUCHI, Brian G.;KONNICK, Michael M.;BISCHOF, Steven M. WO2014/130987, 2014, A1 Location in patent:Page/Page column 30; 31

407-25-0 Synthesis