Picolinic acid, 3-ethyl- (6CI,7CI,8CI) synthesis

9synthesis methods

Product Name:Picolinic acid, 3-ethyl- (6CI,7CI,8CI)
CAS Number:4116-88-5
Molecular formula:C8H9NO2
Molecular Weight:151.16

62733-99-7 Synthesis

3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

62733-99-7
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2: lithium chloride / trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 4 h / 100 °C
3: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C
4: water; lithium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C

References:

BRISTOL-MYERS SQUIBB COMPANY;PACK, Shawn, K.;TYMONKO, Steven;PATEL, Bharat, P.;NATALIE, JR., Kenneth, J.;BELEMA, Makonen WO2011/59850, 2011, A1

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4116-88-5
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References

2-Pyridinecarboxylic acid, 3-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester

157865-84-4
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4116-88-5
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References

2-Pyridinecarboxylicacid,3-ethenyl-,methylester(9CI)

174681-86-8
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4116-88-5
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References

14159-59-2
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$217.80/250mg

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References