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ChemicalBook CAS DataBase List Proadifen

Proadifen synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.) sodamide / 1.) benzene, reflux, 2 h, 2.) benzene, reflux, 2 h
2: 18 percent / 70percent aq.H2SO4 / 48 h / 150 °C
3: SOCl2 / 1 h / Heating
4: benzene / 20 h / Heating

References:

Lu, Mattias C.;Wung, Walley E.;Shih, Lisa B.;Callejas, Soledad;Gearien, James E.;Thompson, Emmanuel B. [Journal of Medicinal Chemistry,1987,vol. 30,# 2,p. 273 - 278]

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