(S)-3-METHYL-2-KETOPIPERAZINE synthesis
- Product Name:(S)-3-METHYL-2-KETOPIPERAZINE
- CAS Number:78551-38-9
- Molecular formula:C5H10N2O
- Molecular Weight:114.15
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Yield:78551-38-9 48%
Reaction Conditions:
in methanol at 50; for 24 h;
Steps:
13.5 5) Preparation of (S)-1-(tert-butoxycarbonyl)-2-methylpiperazin-3-one (13-8)
Methyl (R) -2- (p-toluenesulfonyloxy) propionate (13-6) (400 mg, 1.55 mmol)And ethylenediamine (88 mg, 1.47 mmol)Dissolved in methanol (50 mL)After the reaction mixture was heated to 50 ° C for 24 hours,Cool to room temperature,After the solvent is concentrated under pressure,The crude product of (S) -3-methylpiperazin-2-one (13-7) was obtained;Then according to the embodiment step 3)This gave 140 mg (S) -1- (tert-butoxycarbonyl) -2-methylpiperazin-3-one (13-8)
References:
CN107174584,2017,A Location in patent:Paragraph 0039