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tert-butyl (4R)-4,5-diamino-5-oxopentanoate synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: ammonium bicarbonate; di-tert-butyl dicarbonate; pyridine / 1,4-dioxane / 24 h
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.33 h

References:

Willems, Marian M.J.H.P.;Zom, Gijs G.;Meeuwenoord, Nico;Ossendorp, Ferry A.;Overkleeft, Herman S.;Van Der Marel, Gijsbert A.;Codee, Jeroen D. C.;Filippov, Dmitri V. [Beilstein Journal of Organic Chemistry,2014,vol. 10,p. 1445 - 1453]

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