tert-Butyl diethylphosphonoacetate synthesis
- Product Name:tert-Butyl diethylphosphonoacetate
- CAS Number:27784-76-5
- Molecular formula:C10H21O5P
- Molecular Weight:252.24
5292-43-3
441 suppliers
$10.00/5g
122-52-1
246 suppliers
$9.00/5g
27784-76-5
259 suppliers
$7.00/10g
Yield:27784-76-5 97%
Reaction Conditions:
at 90; for 6 h;Inert atmosphere;
Steps:
2 Example 2 Preparation of Compound 2 (R3 = Et)(Diethoxy-phosphoryl)-acetic acid tert-butyl ester
Triethyl phosphite (485 g) is warmed up to 90°C under N2 atmosphere in a three-necked round-bottomed flask, and /-butyl bromoacetate (541 g) is added dropwise into the system within 2 h. Then the mixture is kept stirring at 90°C for around 4 h, and then cooled to room temperature. The obtained mixture is distilled under vacuo to remove compounds with low boiling point, and the residue is collected as a colorless liquid compound 5 in 97% yield (680 g) and >98% GC purity.
References:
BOEHRINGER INGELHEIM INTERNATIONAL TRADING (SHANGHAI) CO., LTD:;BOEHRINGER INGELHEIM INTERNATIONAL GMBH;ZHENG, Juncheng;DENG, Da;LV, Guanghua;YAN, Jun;BRANDENBURG, Joerg;KROEBER, Jutta;SCHOLZ, Ulrich WO2015/101554, 2015, A1 Location in patent:Page/Page column 17
926-02-3
136 suppliers
$66.50/5g
762-04-9
318 suppliers
$10.00/10 g
27784-76-5
259 suppliers
$7.00/10g
107-59-5
285 suppliers
$26.19/25g
762-04-9
318 suppliers
$10.00/10 g
27784-76-5
259 suppliers
$7.00/10g
3095-95-2
203 suppliers
$6.00/1g
75-65-0
739 suppliers
$10.00/10ml
27784-76-5
259 suppliers
$7.00/10g
540-88-5
350 suppliers
$21.00/25mL
814-49-3
5 suppliers
$37.79/25g
27784-76-5
259 suppliers
$7.00/10g