| Identification | Back Directory | [Name]
Voruciclib | [CAS]
1000023-04-0 | [Synonyms]
CS-2788
P1446A05
P1446A-05
P1446A 05
Voruciclib
UNII-W66XP666AM
Voruciclib (P1446A-05)
P1446A05; P1446A-05; P1446A 05; VORUCICLIB
2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]- | [Molecular Formula]
C22H19ClF3NO5 | [MOL File]
1000023-04-0.mol | [Molecular Weight]
469.84 |
| Chemical Properties | Back Directory | [Boiling point ]
587.6±50.0 °C(Predicted) | [density ]
1.493±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [pka]
6.36±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Voruciclib is a cyclin-dependent kinase (CDK) inhibitor. It is a derivative of Flavone (F371050) and can be used for treatment of proliferative disorders such as cancer. | [in vivo]
Combination of Voruciclib hydrochloride (200 mpk; Oral gavage) and Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL[1]. | Animal Model: | ABC subtypes (U2932, RIVA, OCI-LY10), GCB subtypes (SU-DHL-4, NU-DHL-1) xenografted in Female NOD.CB17-Prkdcscid/NCrHsd mice | | Dosage: | 200 mpk | | Administration: |
Oral gavage; U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), OCI-LY10 (six days per week for 2 weeks), NU-DHL-1 (five days per week for 3 weeks) | | Result: | Enhanced tumor growth inhibition in U2932, RIVA, SU-DHL-4 and NU-DHL-1 models except in OCI-LY10 model.
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| [IC 50]
CDK9/cyc T2: 0.626 nM (Ki); CDK9/CycT1: 1.68 nM (Ki); CDK6/cycD1: 2.92 nM (Ki); CDK4/Cyc D1: 3.96 nM (Ki); CDK1/cycB: 5.4 nM (Ki); CDK1/cyc A: 9.1 nM (Ki) | [storage]
Store at -20°C |
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