| Identification | Back Directory | [Name]
THPN | [CAS]
100079-26-3 | [Synonyms]
THPN
THPN >=98% (HPLC)
1-(3,4,5-Trihydroxyphenyl)-1-nonanone
1-Nonanone, 1-(3,4,5-trihydroxyphenyl)- | [Molecular Formula]
C15H22O4 | [MDL Number]
MFCD31656702 | [MOL File]
100079-26-3.mol | [Molecular Weight]
266.33 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [color ]
white to beige | [InChI]
1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3 | [InChIKey]
NVFRHTFJDGAFQS-UHFFFAOYSA-N | [SMILES]
OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1 |
| Hazard Information | Back Directory | [Uses]
THPN is a Nur77 agonist. THPN binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines. | [General Description]
THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B. | [Biochem/physiol Actions]
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model. | [IC 50]
Nur77/NR4A1 |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|