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1000998-62-8

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1000998-62-8 Structure

1000998-62-8 Structure
IdentificationBack Directory
[Name]

BMS711939
[CAS]

1000998-62-8
[Synonyms]

BMS711939
N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-n-(methoxycarbonyl)glycine
Glycine, N-[[5-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]-2-fluorophenyl]methyl]-N-(methoxycarbonyl)-
[Molecular Formula]

C22H20ClFN2O6
[MDL Number]

MFCD31556555
[MOL File]

1000998-62-8.mol
[Molecular Weight]

462.86
Chemical PropertiesBack Directory
[Boiling point ]

650.1±65.0 °C(Predicted)
[density ]

1.379±0.06 g/cm3(Predicted)
[pka]

3.90±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC50 of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides[1].
[IC 50]

hPPARα: 4 nM (IC50); hPPARγ: 4.5 μM (IC50)
[References]

[1] Shi Y, et al., Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. DOI:10.1021/acsmedchemlett.6b00033
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