| Identification | Back Directory | [Name]
SHP-627 | [CAS]
1001288-58-9 | [Synonyms]
FT011
SHP-627
FT011;SHP-627
(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid
Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]- | [Molecular Formula]
C20H17NO5 | [MDL Number]
MFCD28502026 | [MOL File]
1001288-58-9.mol | [Molecular Weight]
351.35 |
| Chemical Properties | Back Directory | [Boiling point ]
618.9±55.0 °C(Predicted) | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 29 mg/mL (82.54 mM) | [form ]
Solid | [pka]
3.45±0.36(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis[1]. FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats[1]. | Animal Model: | Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)[1] | | Dosage: | 100 mg/kg | | Administration: | B.I.D., p.o. on day 7 after surgery, for 4 weeks | | Result: | Increased ejection fraction, fraction shortening and preload recruitable stroke work. |
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| Company Name: |
Twochem Co.Ltd
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| Tel: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
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