1001401-62-2

88-67-5

288-36-8

1001401-62-2

1. To a 100 mL single-necked round-bottomed flask under nitrogen protection, 1,2,3-triazole (0.7 mmol), 2-iodobenzoic acid (1.0 mmol), cesium carbonate (2.36 g, 7.20 mmol), trans-N,N'-dimethyl-1,2-cyclohexane-1,2-diamine (0.10 g, 0.75 mmol), copper(II) iodide (0.08 g, 0.40 mmol) and N,N-dimethylformamide (18 mL) were added in sequence. 0.40 mmol) and N,N-dimethylformamide (18 mL). 2. The reaction mixture was gradually warmed to 100 °C and the reaction was stirred at this temperature for 4 hours. 3. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with tap water. 4. The aqueous layer was extracted with ethyl acetate (200 mL × 2). 5. Combine the organic layers and dry with anhydrous sodium sulfate. 6. 6. Evaporate the filtrate under pressure to obtain the crude product. 7. The crude product was purified by column chromatography using dichloromethane/methanol (v/v = 30/1) as eluent to afford 2-(2H-1,2,3-triazol-2-yl)benzoic acid (yellow solid, 0.511 g, 67% yield).