| Identification | Back Directory | [Name]
Rustmicin | [CAS]
100227-57-4 | [Synonyms]
Rustmicin
Galbonolide A
Galbonolides B
(-)-Galbonolide A
(3R,5S,7Z,9S,12E,14S)-14-Ethyl-5-hydroxy-5-(hydroxymethyl)-7-methoxy-3,9,13-trimethyl-11-methylene-1-oxacyclotetradeca-7,12-diene-2,4-dione | [MOL File]
100227-57-4.mol |
| Hazard Information | Back Directory | [Description]
Rustmicin is a 14-membered macrolide identified as an inhibitor of plant pathogenic fungi. | [Uses]
Galbonolide A (Rustmicin) is a potent antifungal agent.Galbonolide A inhibits inositol phosphoceramide synthase. Galbonolide A shows antifungal activity[1]. | [in vivo]
Galbonolide A (Rustmicin) (0, 10, 20, 40, 80 mg/kg; i.p.; twice daily for 4 days) shows antifungal activity in mouse model for cryptococcosis[1]. | Animal Model: | DBA/2N mice (Cryptococcus neoformans MY2061)[1] | | Dosage: | 0, 10, 20, 40, 80 mg/kg | | Administration: | I.p.; twice daily for 4 days | | Result: | Showed a dose-dependent reduction in colony-forming units isolated from spleen and brain tissue of mice, with the ED99 value of 29 mg/kg for both tissues. |
| [References]
[1] Mandala SM, et al. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J Biol Chem. 1998 Jun 12;273(24):14942-9. DOI:10.1074/jbc.273.24.14942 |
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