| Identification | Back Directory | [Name]
(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | [CAS]
1005036-73-6 | [Synonyms]
GCA
(Rac)-GCA
CID 25113626
rac-Golgicide A
Recombinant Human Grancalcin/GCA Protein, Gst Tag
(3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | [Molecular Formula]
C17H14F2N2 | [MDL Number]
MFCD27937048 | [MOL File]
1005036-73-6.mol | [Molecular Weight]
284.303 |
| Chemical Properties | Back Directory | [Boiling point ]
383.0±42.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [pka]
4.84±0.12(Predicted) | [InChI]
1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1 | [InChIKey]
NJZHEQOUHLZCOX-FTLRAWMYSA-N | [SMILES]
Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4 |
| Hazard Information | Back Directory | [Uses]
Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells. | [Definition]
ChEBI: 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is an organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline which is substituted by a pyridin-3-yl at position 4 and by fluorines at positions 6 and 8. It is an organic heterotricyclic compound, a member of pyridines, an organofluorine compound and a secondary amino compound. | [Biochem/physiol Actions]
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation. |
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