| Identification | Back Directory | [Name]
Adibendan | [CAS]
100510-33-6 | [Synonyms]
BM-14478
Adibendan
5,7-Dihydro-7,7-dimethyl-2-(pyridin-4-yl)pyrrolo[2,3-f]benzimidazol-6(1H)-one | [Molecular Formula]
C16H14N4O | [MDL Number]
MFCD00867123 | [MOL File]
100510-33-6.mol | [Molecular Weight]
278.314 |
| Hazard Information | Back Directory | [Uses]
Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent[1]. | [References]
[1] T Bethke, et al. Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):576-82. DOI:10.1007/BF00182735 |
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