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100510-33-6

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100510-33-6 Structure

100510-33-6 Structure
IdentificationBack Directory
[Name]

Adibendan
[CAS]

100510-33-6
[Synonyms]

BM-14478
Adibendan
5,7-Dihydro-7,7-dimethyl-2-(pyridin-4-yl)pyrrolo[2,3-f]benzimidazol-6(1H)-one
[Molecular Formula]

C16H14N4O
[MDL Number]

MFCD00867123
[MOL File]

100510-33-6.mol
[Molecular Weight]

278.314
Chemical PropertiesBack Directory
[Melting point ]

285-288 °C(Solv: methanol (67-56-1))
[density ]

1.302±0.06 g/cm3(Predicted)
[pka]

9.72±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent[1].
[References]

[1] T Bethke, et al. Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):576-82. DOI:10.1007/BF00182735
Spectrum DetailBack Directory
[Spectrum Detail]

Adibendan(100510-33-6)1HNMR
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