| Identification | Back Directory | [Name]
4-[[5-[(3,5-dimethylpyrazol-1-yl)methyl]furan-2-carbonyl]amino]-1-ethylpyrazole-3-carboxamide | [CAS]
1005636-29-2 | [Synonyms]
CLB016
CLB-016
CLB 016
4-[[5-[(3,5-dimethylpyrazol-1-yl)methyl]furan-2-carbonyl]amino]-1-ethylpyrazole-3-carboxamide | [Molecular Formula]
C17H20N6O3 | [MOL File]
1005636-29-2.mol | [Molecular Weight]
356.379 |
| Hazard Information | Back Directory | [Description]
CLB-016 is a hypoxia-inducible factor (HIF)-1 inhibitor. | [Uses]
CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response[1]. | [References]
[1] Yasuda Y, et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorg Med Chem. 2015 Apr 15;23(8):1776-87. DOI:10.1016/j.bmc.2015.02.038 |
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