| Identification | Back Directory | [Name]
Benzamide, 4-[1,1-dimethyl-3-(2H-tetrazol-5-yl)propyl]-N-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]- | [CAS]
1005784-23-5 | [Synonyms]
CLK1/2IN1
CLK1/2-IN-1
CLK1/2 IN 1
CLK1/2 inhibitor 1
CLK1/2-inhibitor-1
Benzamide, 4-[1,1-dimethyl-3-(2H-tetrazol-5-yl)propyl]-N-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]- | [Molecular Formula]
C21H20F3N7O | [MOL File]
1005784-23-5.mol | [Molecular Weight]
443.42 |
| Hazard Information | Back Directory | [Description]
CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor. It also inhibits SRPK1 and SRPK2. | [Uses]
CLK1/2-IN-2 is CLK1 and CLK2 inhibitor with IC50 values of 16 nM and 45 nM, respectively. CLK1/2-IN-2 exhibits potent anti-cancer activities[1]. | [IC 50]
CLK1: 16 nM (IC50); CLK2: 45 nM (IC50) | [References]
[1] Shinsuke Araki, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One DOI:10.1371/journal.pone.0116929 |
|
|