| Identification | Back Directory | [Name]
p38 MAPK-IN-1 | [CAS]
1006378-90-0 | [Synonyms]
CS-2117
p38 MAPK-IN-4
p38 MAPK-IN-1
1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide | [Molecular Formula]
C21H14F2N2O | [MDL Number]
MFCD28900744 | [MOL File]
1006378-90-0.mol | [Molecular Weight]
348.35 |
| Chemical Properties | Back Directory | [Boiling point ]
527.0±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 8.33 mg/mL (23.84 mM) | [form ]
Solid | [pka]
0.26±0.40(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability. | [in vivo]
p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po in male wistar rats[1].
p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED50 of 0.5 mg/kg[1].
| Animal Model: | Male wistar rats[1] | | Dosage: | 10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis) | | Administration: | Po and iv | | Result: | Had a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po.
|
| [IC 50]
p38 MAPK: 68 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910. DOI:10.1021/jm200975u |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|