| Identification | Back Directory | [Name]
LY 186126 | [CAS]
100644-00-6 | [Synonyms]
LY 186126
1,3-Dihydro-1,3,3-trimethyl-5-[(1,4,5,6-tetrahydro-4-methyl-6-oxopyridazin)-3-yl]-2H-indol-2-one | [Molecular Formula]
C16H19N3O2 | [MOL File]
100644-00-6.mol | [Molecular Weight]
285.34 |
| Hazard Information | Back Directory | [Description]
LY 186126 is a potent cGI-PDE inhibitor. It exhibit reversible, high affinity (Ka = 6 nM) binding to a single class of SaR binding sites. | [Uses]
LY 186126 a Indolidan analog, is a phosphodiesterase (PDE) inhibitor. LY 186126 binds to cardiac sarcoplasmic reticulum PDE with high affinity, with a Kd of 5.6 nM[1]. | [References]
[1] T Ashikaga, et al. Comparison of indolidan analog binding sites of drug antibody and sarcoplasmic reticulum with inhibition of cyclic AMP phosphodiesterase. J Recept Signal Transduct Res. 1996 Sep-Nov;16(5-6):315-37. DOI:10.3109/10799899609039954 |
|
|