| Identification | Back Directory | [Name]
1,4-Dihydro-N-[(1S,2R)-2-hydroxy-3-oxo-1-(phenylmethyl)-3-[(phenylmethyl)amino]propyl]-3-methyl-4-oxo-2-quinolinecarboxamide | [CAS]
1007567-02-3 | [Synonyms]
1,4-Dihydro-N-[(1S,2R)-2-hydroxy-3-oxo-1-(phenylmethyl)-3-[(phenylmethyl)amino]propyl]-3-methyl-4-oxo-2-quinolinecarboxamide | [Molecular Formula]
C28H27N3O4 | [MOL File]
1007567-02-3.mol | [Molecular Weight]
469.53 |
| Chemical Properties | Back Directory | [Boiling point ]
794.6±60.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
12.29±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells[1]. | [References]
[1] Hassan AHE, et al. Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies. Eur J Med Chem. 2023 Mar 15;250:115211. DOI:10.1016/j.ejmech.2023.115211
[2] Hassan AHE, et, al. Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies. Eur J Med Chem. 2023 Mar 15;250:115211. DOI:10.1016/j.ejmech.2023.115211 |
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