| Identification | Back Directory | [Name]
(E)-N-(2-(2,5-Dihydroxyphenyl)ethenyl)formamide | [CAS]
100827-28-9 | [Synonyms]
erbstatin
N-[(E)-2-(2,5-Dihydroxyphenyl)ethenyl]formamide
(E)-N-(2-(2,5-Dihydroxyphenyl)ethenyl)formamide | [MDL Number]
MFCD00871557 | [MOL File]
100827-28-9.mol |
| Hazard Information | Back Directory | [Uses]
Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2]. | [References]
[1] Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src(ts)NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1585-92. DOI:10.1248/cpb.55.1585
[2] M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4. DOI:10.1016/0277-5379(90)90126-e
[3] S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56(21):4978-82. PMID:8895753 |
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