| Hazard Information | Back Directory | [Description]
Ro 14-9578 is a tricyclic quinolone antibacterial agent. | [Uses]
Ro 14-9578 is a tricyclic quinolone analog with antibacterial activity. Ro 14-9578 inhibits DNA biosynthesis (IC50=117 μM) and DNA supercoiling (IC50=66.8 μM) in Escherichia coli. Furthermore, Ro 14-9578 exhibits inhibitory effects against various Gram-negative bacteria and Staphylococcus aureus[1]. | [References]
[1] Georgopapadakou N H, et al. Monocyclic and tricyclic analogs of quinolones: mechanism of action[J]. Antimicrobial agents and chemotherapy, 1987, 31(4): 614-616. DOI:10.1128/AAC.31.4.614 |
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