| Identification | Back Directory | [Name]
PYRIMIDO[4,5-C]QUINOLINE-8-CARBOXYLIC ACID, 5-[(3-ETHYNYLPHENYL)AMINO]- | [CAS]
1009821-06-0 | [Synonyms]
CX-5011
5-[(3-Ethynylphenyl)amino]-Pyrimido[4,5-c]quinoline-8-carboxylic acid
PYRIMIDO[4,5-C]QUINOLINE-8-CARBOXYLIC ACID, 5-[(3-ETHYNYLPHENYL)AMINO]- | [Molecular Formula]
C20H12N4O2 | [MDL Number]
MFCD11977745 | [MOL File]
1009821-06-0.mol | [Molecular Weight]
340.33 |
| Hazard Information | Back Directory | [Uses]
CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation[1][2]. | [References]
[1] D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807. DOI:10.1016/j.bbamcr.2020.118807
[2] Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18. DOI:10.18632/oncotarget.7569 |
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