| Identification | Back Directory | [Name]
ODZXEQVQLJKSQH-UHFFFAOYSA-N | [CAS]
1010100-22-7 | [Synonyms]
ODZXEQVQLJKSQH-UHFFFAOYSA-N
Thalidomide-5-CH2-NH2 (hydrochloride)
5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
1H-Isoindole-1,3(2H)-dione, 5-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [Molecular Formula]
C14H14ClN3O4 | [MDL Number]
MFCD32666042 | [MOL File]
1010100-22-7.mol | [Molecular Weight]
323.73 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] Makbul C, Nassal M, B?ttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14. DOI:10.7554/eLife.57277
[2] Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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