| Identification | Back Directory | [Name]
artemisitene | [CAS]
101020-89-7 | [Synonyms]
Artemisiten
artemisitene
Dehydroqinghaosu
Methyl Artemisinin
ArteMisitene (Methyl ArteMisinin)
(3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-diMethyl-9-Methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-methylene-, (3R,5aS,6R,8aS,12S,12aR)-
Artemisinin and Piperaquine Tablets Impurity Ⅰ:(artemisitene)(3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-diMethyl-9-Methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-oneChemicalBook
Artemisinin and Piperaquine Tablets Impurity Ⅰ:(artemisitene)(3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-diMethyl-9-Methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-oneChemicalBook | [Molecular Formula]
C15H20O5 | [MDL Number]
MFCD19443385 | [MOL File]
101020-89-7.mol | [Molecular Weight]
280.32 |
| Chemical Properties | Back Directory | [Melting point ]
160-162°C | [Boiling point ]
417.5±45.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C15H20O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8,10-11,13H,2,4-7H2,1,3H3/t8-,10+,11+,13-,14-,15-/m1/s1 | [InChIKey]
IGEBZMMCKFUABB-KPHNHPKPSA-N | [SMILES]
O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])C(=C)C(=O)O4)O1 | [LogP]
0.733 (est) |
| Hazard Information | Back Directory | [Uses]
Artemisitene, the oxidized form of Artemisinin (A777500), exists as a minor constituent in an American variant of Artemisia annua. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinic acid, Artemisinin B, Artemisitene, etc. An antimalarial agent. | [in vivo]
In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1]. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|