| Identification | Back Directory | [Name]
4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester | [CAS]
1010820-68-4 | [Synonyms]
SW02
4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester
1(2H)-Pyrimidinebutanoic acid, 4-(4-bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-, methyl ester | [Molecular Formula]
C19H23BrN2O5 | [MDL Number]
MFCD17215960 | [MOL File]
1010820-68-4.mol | [Molecular Weight]
439.3 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [color ]
white to off-white | [InChI]
1S/C19H23BrN2O5/c1-4-27-18(24)16-12(2)22(11-5-6-15(23)26-3)19(25)21-17(16)13-7-9-14(20)10-8-13/h7-10,17H,4-6,11H2,1-3H3,(H,21,25) | [InChIKey]
YFZRMRYVWWUQME-UHFFFAOYSA-N | [SMILES]
CCOC(=O)C1=C(C)N(CCCC(=O)OC)C(=O)NC1c2ccc(Br)cc2 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Uses]
SW02 may be used in Hsp70-mediated cell signaling studies. | [Biological Activity]
SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfoldingsuch as tau and Aβ in Alzheimerμs. SW02 increases Hsp70 ATPase activityresulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptideas shown by treatment with SW02. | [IC 50]
TRAP1 ATPase: 150 ± 21 μM (EC50) |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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