| Identification | Back Directory | [Name]
2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- | [CAS]
1011244-19-1 | [Synonyms]
Monascuspiloin
2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- | [Molecular Formula]
C21H28O5 | [MOL File]
1011244-19-1.mol | [Molecular Weight]
360.44 |
| Chemical Properties | Back Directory | [Boiling point ]
577.9±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: Soluble
Methanol: Soluble | [form ]
A solid | [pka]
14.43±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice[1][2]. | [Biological Activity]
Monascuspiloin is a fungal metabolite that has been found in M. pilosus M93-fermented rice.1 It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 and 120 mg/kg.2 | [References]
1.Chiu, H.-W., Fang, W.-H., Chen, Y.-L., et al.Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagyPLoS One7(7)e40462(2012)
2.Chen, R.-J., Hung, C.-M., Chen, Y.-L., et al.Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathwaysJ. Agric. Food Chem.60(29)7185-7193(2012)
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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