| Identification | Back Directory | [Name]
D-Ribose, 5-(trihydrogen diphosphate), P'→5'-ester with 6-bromo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | [CAS]
1011457-95-6 | [Synonyms]
D-Ribose, 5-(trihydrogen diphosphate), P'→5'-ester with 6-bromo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | [Molecular Formula]
C16H23BrN4O14P2 | [MOL File]
1011457-95-6.mol | [Molecular Weight]
637.22 |
| Hazard Information | Back Directory | [Uses]
8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes[1]. | [References]
[1] Moreau, et al. Structure–activity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. Journal of Medicinal Chemistry 56.24 (2013): 10079-10102. DOI:10.1021/jm401497a |
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| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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