| Identification | Back Directory | [Name]
H 0106 2HCl | [CAS]
1011465-90-9 | [Synonyms]
H0106 2HCl
H 0106 2HCl
H0106 Dihydrochloride
H-0106 Dihydrochloride
H 0106 Dihydrochloride | [Molecular Formula]
C16H21Cl2N3O2S | [MDL Number]
MFCD28160563 | [MOL File]
1011465-90-9.mol | [Molecular Weight]
390.32 |
| Hazard Information | Back Directory | [Description]
H-0106 Dihydrochloride is a Rho-associated coiled coil-formed protein kinase (ROCK) inhibitor that acts by exerting strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys. | [Uses]
H-0106 dihydrochloride is a ROCK inhibitor with potent intraocular pressure (IOP)-lowering activity. H-0106 dihydrochloride can effectively inhibit ROCK enzyme. H-0106 dihydrochloride demonstrated significant IOP-lowering effects in monkey eyes. Studies with H-0106 dihydrochloride suggest that there may not be a direct relationship between ROCK inhibition and IOP reduction[1]. | [References]
[1] IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys DOI:10.1016/j.bmcl.2013.12.085 |
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