| Identification | Back Directory | [Name]
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole | [CAS]
101189-47-3 | [Synonyms]
CP-66,948
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-
1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine | [Molecular Formula]
C13H20N6S | [MDL Number]
MFCD00906932 | [MOL File]
101189-47-3.mol | [Molecular Weight]
292.4 |
| Chemical Properties | Back Directory | [Boiling point ]
517.0±42.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
11.38±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. | [in vivo]
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously)[1]. | [IC 50]
H2 Receptor | [References]
[1] J P Hakkinen, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8. DOI:10.1007/BF01296616
[2] Hakkinen JP, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8. |
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