101189-47-3

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101189-47-3 Structure

Identification	Back Directory
[Name] 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
[CAS] 101189-47-3
[Synonyms] CP-66,948 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl- 1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
[Molecular Formula] C13H20N6S
[MDL Number] MFCD00906932
[MOL File] 101189-47-3.mol
[Molecular Weight] 292.4

Hazard Information	Back Directory
[Uses] CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.
[in vivo] The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED₅₀ value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED₅₀ values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED₅₀ values of 12 mg/kg per os and 6 mg/kg subcutaneously)^[1].
[IC 50] H₂ Receptor
[References] [1] J P Hakkinen, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8. DOI:10.1007/BF01296616 [2] Hakkinen JP, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8.

Spectrum Detail	Back Directory
[Spectrum Detail] 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole(101189-47-3)¹HNMR

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