| Identification | Back Directory | [Name]
4-Hydroxycanthin-6-one | [CAS]
101219-61-8 | [Synonyms]
Picrasidine Q
4-Hydroxycanthin-6-one
4-Hydroxy-5-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 4-hydroxy-5-methoxy- | [Molecular Formula]
C15H10N2O3 | [MOL File]
101219-61-8.mol | [Molecular Weight]
266.25 |
| Hazard Information | Back Directory | [Uses]
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1]. | [IC 50]
FGFR2 | [References]
[1] Shi Y, et al. FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. J Cell Biochem. 2018;119(2):2231-2239. DOI:10.1002/jcb.26385 |
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