| Identification | Back Directory | [Name]
CAY10607 | [CAS]
1012788-65-6 | [Synonyms]
CAY10607
CAY10607 Exclusive
Benzisoxazole Hsp90 Inhibitor
1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]- | [Molecular Formula]
C19H20ClN3O4 | [MDL Number]
MFCD18382085 | [MOL File]
1012788-65-6.mol | [Molecular Weight]
389.83 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 μM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 μM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 μM for both. | [Uses]
Benzisoxazole Hsp90 Inhibitor is an inhibitor that binds to the N-terminal domain of Hsp90. | [Definition]
ChEBI: 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol is a member of the class of 1,2-benzoxazoles carrying 2,4-dihydroxy-4-chlorophenyl and (2-morpholin-4-ylethyl)amino substituents at positions 3 and 5 respectively. It has a role as a Hsp90 inhibitor. It is a member of 1,2-benzoxazoles, a member of morpholines, a member of resorcinols, a member of monochlorobenzenes, a tertiary amino compound, a secondary amino compound and an aromatic amine. | [IC 50]
HSP90: 30 nM (IC50) | [References]
[1] ARIAMALA GOPALSAMY*. Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90[J]. Journal of Medicinal Chemistry, 2008, 51 3: 373-375. DOI: 10.1021/jm701385c |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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