| Identification | Back Directory | [Name]
CP-24879 HYDROCHLORIDE | [CAS]
10141-51-2 | [Synonyms]
CP-24879
CP-24879 HCl
p-isopentoxyaniline
CP-24879 HYDROCHLORIDE
Benzenamine, 4-(3-methylbutoxy)-
P-ISOPENTOXYANILINE HYDROCHLORIDE
a€￠ Benzenamine, 4-(3-methylbutoxy)-
P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
CP-24879 hydrochloride >=98% (HPLC), powder
4-(3-METHYLBUTOXY)-BENZENAMINE HYDROCHLORIDE | [Molecular Formula]
C11H18ClNO | [MDL Number]
MFCD05863938 | [MOL File]
10141-51-2.mol | [Molecular Weight]
215.72 |
| Chemical Properties | Back Directory | [Melting point ]
154-159 °C | [storage temp. ]
room temp | [solubility ]
DMSO: 22 mg/mL | [form ]
solid | [color ]
off-white | [InChI]
1S/C11H17NO.ClH/c1-9(2)7-8-13-11-5-3-10(12)4-6-11;/h3-6,9H,7-8,12H2,1-2H3;1H | [InChIKey]
GFESZSNFRSACMU-UHFFFAOYSA-N | [SMILES]
Cl[H].CC(C)CCOc1ccc(N)cc1 |
| Hazard Information | Back Directory | [Uses]
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2]. | [Biochem/physiol Actions]
delta5/delta6 (Δ5/Δ6) desaturase inhibitor. | [in vivo]
CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1]. | Animal Model: | Chow-fed and EFAD Balb/C mice (N = 5/group) [1] | | Dosage: | 3 mg/kg | | Administration: | IP, three times a day, for 6 or 4 days | | Result: | Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively). |
| Animal Model: | Swiss-Webster mice (male, 25 g) [1] | | Dosage: | 33 mg/kg | | Administration: | IV in the tail vein, once (Pharmacokinetic Analysis) | | Result: | Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min). |
| [References]
[1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117 |
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Sigma-Aldrich
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Energy Chemical
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http://www.energy-chemical.com |
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