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10141-51-2

10141-51-2 Structure

10141-51-2 Structure
IdentificationBack Directory
[Name]

CP-24879 HYDROCHLORIDE
[CAS]

10141-51-2
[Synonyms]

CP-24879
CP-24879 HCl
p-isopentoxyaniline
CP-24879 HYDROCHLORIDE
Benzenamine, 4-(3-methylbutoxy)-
P-ISOPENTOXYANILINE HYDROCHLORIDE
a€¢ Benzenamine, 4-(3-methylbutoxy)-
P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
CP-24879 hydrochloride >=98% (HPLC), powder
4-(3-METHYLBUTOXY)-BENZENAMINE HYDROCHLORIDE
[Molecular Formula]

C11H18ClNO
[MDL Number]

MFCD05863938
[MOL File]

10141-51-2.mol
[Molecular Weight]

215.72
Chemical PropertiesBack Directory
[Melting point ]

154-159 °C
[storage temp. ]

room temp
[solubility ]

DMSO: 22 mg/mL
[form ]

solid
[color ]

off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].
[Biochem/physiol Actions]

delta5/delta6 (Δ5/Δ6) desaturase inhibitor.
[in vivo]

CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1].

Animal Model:Chow-fed and EFAD Balb/C mice (N = 5/group) [1]
Dosage:3 mg/kg
Administration:IP, three times a day, for 6 or 4 days
Result:Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
Animal Model:Swiss-Webster mice (male, 25 g) [1]
Dosage:33 mg/kg
Administration:IV in the tail vein, once (Pharmacokinetic Analysis)
Result:Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min).
[References]

[1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117
Spectrum DetailBack Directory
[Spectrum Detail]

CP-24879 HYDROCHLORIDE(10141-51-2)1HNMR
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