| Identification | Back Directory | [Name]
L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-, 2-[[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazide | [CAS]
1014405-03-8 | [Synonyms]
Oxocarbazate
L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-, 2-[[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazide | [Molecular Formula]
C28 H33 N5 O6 | [MOL File]
1014405-03-8.mol | [Molecular Weight]
535.59 |
| Hazard Information | Back Directory | [Uses]
Oxocarbazate is an inhibitor of human cathepsin L with the IC50 values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into 293T cells[1]. | [References]
[1] Shah PP, et al. A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol. 2010;78(2):319-324. DOI:10.1124/mol.110.064261 |
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