| Identification | Back Directory | [Name]
Carbamic acid, diphenyl-, 1-methyl-4-piperidinyl ester (9CI) | [CAS]
101491-79-6 | [Synonyms]
mAChR antagonist 1
Carbamic acid, diphenyl-, 1-methyl-4-piperidinyl ester (9CI) | [Molecular Formula]
C19H22N2O2 | [MOL File]
101491-79-6.mol | [Molecular Weight]
310.39 |
| Chemical Properties | Back Directory | [Boiling point ]
437.0±38.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.84±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1]. | [IC 50]
mAChR1: 255 nM (Ki); mAChR3: 121 nM (Ki); mAChR4: 158 nM (Ki); mAChR5: 255 nM (Ki); mAChR2: >1000 nM (Ki) | [References]
[1] Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891. DOI:10.1016/j.ejmech.2023.115891 |
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