| Identification | Back Directory | [Name]
D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate | [CAS]
1015698-39-1 | [Synonyms]
D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate | [Molecular Formula]
C19H27N3O10 | [MOL File]
1015698-39-1.mol | [Molecular Weight]
457.43 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [solubility ]
Ethanol:45.74(Max Conc. mg/mL);100.0(Max Conc. mM)
DMSO:45.74(Max Conc. mg/mL);100.0(Max Conc. mM) | [pka]
12.89±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Ac4ManNDAz is a cell-permeable photo-crosslinking probe for studying glycoprotein or glycolipid interactions. The compound is an unnatural diazirine-containing monosaccharide building block, which acts as a photo-crosslinker. Once inside the cell, Ac4ManNDAz is metabolized and incorporated as photo-crosslinking sialic acid analogs into cell surface glycoproteins. Upon photoactivation with UV irradiation, the sialic acid appended diazirine is activated to a reactive carbene that covalently crosslinks to nearby molecules. | [Uses]
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins[1]. | [storage]
Store at -20°C | [References]
[1] Tanaka Y, et al. Photoactivatable crosslinking sugars for capturing glycoprotein interactions. J Am Chem Soc. 2008 Mar 19;130(11):3278-9. DOI:10.1021/ja7109772 |
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