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101626-70-4

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101626-70-4 Structure

101626-70-4 Structure
IdentificationBack Directory
[Name]

TALIPEXOLE
[CAS]

101626-70-4
[Synonyms]

Domin
Talipexol
TALIPEXOLE
Talipexolum
Talipexolum [latin]
Talipexol [spanish]
TALIPEXOLE USP/EP/BP
6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
[Molecular Formula]

C10H15N3S
[MDL Number]

MFCD00867565
[MOL File]

101626-70-4.mol
[Molecular Weight]

209.31
Chemical PropertiesBack Directory
[Boiling point ]

364.6±37.0 °C(Predicted)
[density ]

1.167±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

7.22±0.20(Predicted)
Hazard InformationBack Directory
[Description]

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.
[Originator]

Boehringer Ingelheim (Germany)
[Definition]

ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.
[Brand name]

Domin
[storage]

Store at -20°C
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